A COX-1-Inhibitor PDF

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    All Chemicals: 34
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    Chemical Dosage References
    (+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM)*
    (-)-EPIAFZELECHIN IC50=15 uM/Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
    3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml*
    AIPHANOL --*
    ANTHOCYANINS IC45=125 ug/ml*
    APIGENIN IC65=1,000 uM*
    BAICALEIN 100 ug/mlFukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
    BETA-CAROTENE IC78=50 ug/ml*
    CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM)*
    CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml*
    CIRSILINEOL IC37=1,000 uM*
    CIRSIMARITIN IC50=1,000 uM*
    CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml*
    DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/mlRamsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
    EUGENOL IC97=1,000 uM*
    FLAVOKAWAIN-B IC77=100 ug/ml*
    FLAVOKAWAIN-B IC55=12.5 ug/ml*
    ISOTHYMONIN IC37=1,000 uM*
    LAURIC-ACID IC40=100*
    MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=10 uM/Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
    *Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.