Chemical Dosage References
LYCACONITINEIC50=74 ug/mlKim, D. K., Kwon, H. Y., Lee, K. R., Rhee, D. K., Zee, O. P. 1998. Isolation of a Multidrug Resistance Inhibitor From Aconitum pseudo-laeve var. erectum. Arch Pharm Research, 21: 344-347.
KOPSIFLORINEIC50=5.6 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSAMINEIC50=5.6 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
QUININEIC50=4-17 uM*
PLEIOCARPINEIC50=3.1 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSININEIC50=25 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
12-METHOXY-PLEIOCARPINEIC50=21 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
LAHADININE-AIC50=2.5 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
(+)-CEPHARANTHINEIC50=2.06 uM*
ARTEMISININIC50=2 uM*
VOACAMINEIC50=2 ug/mlYou, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
KOPSILONGINEIC50=15.4 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
CORONARIDINEIC50=1.9 ug/mlYou, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
11-METHOXY-KOPSILONGINEIC50=1.6 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
CELAFOLIN-A1IC50=1.45 uMKim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELORBICOL-ESTERIC50=1.36 uMKim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
QUINIDINEIC50=1-12 uM*
CELAFOLIN-A1IC50=0.77 uMKim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CONODURAMINEIC50=0.6 ug/mlYou, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
DEMECOLCINEED50=78 ng/mlTang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICIDEED50=410 ng/mlTang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DEACETYL-COLCHICEINEED50=27 ng/mlTang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICEINEED50=15 ng/mlTang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
GINSENOSIDE-RD50 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
BRAZILIN50 mg/kg ipr musChoi, S. Y., Yang, K. M., Jeon, S. D., Kim, J. H., Khil, L. Y., Chang, T. S., Moon, C. K. 1997. Brazilin Modulates Immune Function Mainly by Augmenting T-Cell Activity in Halothane Administered Mice. Planta Medica, 63: 405-408.
DENDROAMIDE-A5 uMOgino, J., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1996. Dendroamides, New Cyclic Hexapeptides From a Blue-Green Alga. Multidrug-Resistance Reversing Activity of Dendroamide A. J. Nat. Prod., 59(6): 581-586.
CINCHONINE5 uM*
CINCHONINE250 mg/kg igs ratGenne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
ZINGIBEROSIDE-R125 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-225 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GENISTEIN200 uMCastro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93.
HAPALOSIN20 uMStratmann, K., Burgoyne, D. L., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1994. Hapalosin, a Cyanobacterial Cyclic Depsipeptide With Multidrug-Resistance Reversing Activity. J Org Chem, 59(24): 7219-7226.
RESERPINE2.5-10 uM*
TOLYPORPHIN-K2.5-10 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1998. Tolyporphins J and K, Two Further Porphinoid Metabolites From the Cyanobacterium Tolypothrix nodosa. J. Nat. Prod., 61(9): 1133-1136.
TOLYPORPHIN-J2.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1998. Tolyporphins J and K, Two Further Porphinoid Metabolites From the Cyanobacterium Tolypothrix nodosa. J. Nat. Prod., 61(9): 1133-1136.
THALICARPINE2 uM*
GINSENOSIDE-RB-1100 uM catHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RC100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
CHALCONE100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
GINSENOSIDE-RE100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-1100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RG-1100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RB-2100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
QUINIDINE100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
VINCALEUKOBLASTINE100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
GINSENOSIDE-RF100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
DIOSMIN100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
GINSENOSIDE-RG-2100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
TORILIN10-30 uM*
INOSTAMYCIN10 uM*
YOHIMBINE10 uMBhat, U. G., et al. 1995. A Structure-Function Relationship Among Reserpine and Yohimbine Analogues in Their Ability to Increase Expression of MDR1 and P-Glycoprotein in a Human Colon Carcinoma Cell Line. Mol Pharmacol, 48(4): 682-689.
5-N-ACETYLARDEEMIN10 uMKarwowski, J. P., et al. 1993. 5-n-acetylkardeemin, a Novel Heterocyclic Compound Which Reverses Multiple Drug Resistance in Tumor Cells I. Taxonomy and Fermentation of the Producing Organism and Biological Activity. J Antibiot, 46(3): 374-379.
2-DEACETOXYTAXININE-E10 ug/ml*
TAXACIN10 ug/mlKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
ISORESERPINE1.6 uMHall, A. M., Croy, V., Chan, T., Ruff, D., Kuczek, T., Chang, C. J. 1996. Bicinchoninic Acid Protein Assay in the Determination of Adriamycin Cytotoxicity Modulated by the MDR Glycoprotein. J Nat Prod, 59(1): 35-40.
CURCUMIN1-55 uM*
TAXININE-B1-10 ug/ml*
7-EPITAXOL1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-D1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
10-DEACETYLBACCATIN-III1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-P1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXININE-A1 ug/mL*
TAXUSPINE-G1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DECINNAMOYL-TAXAGIFINE1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXACUSTIN1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
BREVIFOLIOL1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-R1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXININE-M1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-J1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAYUNTIN1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-T1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DEACETYL-5-DECINNAMOYLTAXININE-J1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-A1 ug/mL*
TAXUSPINE-L1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TRIACETYLTAXICIN-I1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
1BETA-HYDROXYBACCATIN-11 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DECINNAMOYLTAXININE-J1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-C1 ug/mL*
TAXUSPINE-O1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXININE1 ug/mL*
2-DEACETOXYAUSTROSPICATINE1 ug/mLKobayashi, J., et al. 1994. Taxuspines A-C, New Taxoids From Japanese New Taxus cuspidata Inhibiting Drug Transport Activityof P-Glycoprotein in Multidrug-Resistant Cells. Tetrahedron, 50(25): 7401-7416.
TAXUSPINE-F1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
(+)-CEPHARANTHINE1 ug/mLHotta,T., Tanimura,H., Yamaue,H., Iwahashi,M., Tani,M., Tsunoda,T., Tamami,M., Moguchi,K., Mizobata,S., Arii,K., Teraswa,H. 1997. Modulation of Multidrug Resistance by Cepharanthine in Fresh Human Gastrointestinal Tumor Cells. Oncology, 54(2): 153-157.
7-O-ACETYLTAXINE-A1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-Q1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
19-ACETYL-19-DEBENZOYLTAXININE-M1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-H1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DIACETYLTAXININE-B1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAGIFINE1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
13-ACETYL-BREVIFOLIOL1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-S1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DEACETOXYTAXININE-J1 ug/mLKobayashi, J., et al. 1994. Taxuspines A-C, New Taxoids From Japanese New Taxus cuspidata Inhibiting Drug Transport Activityof P-Glycoprotein in Multidrug-Resistant Cells. Tetrahedron, 50(25): 7401-7416.
2,9-DIDEACETYLTAXININE1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-K1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXCHININ-B1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
2-DEACETYLTAXININE-J1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-B1 ug/mL*
TAXUSPINE-M1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXINE-II1 ug/mL*
2',7-DIDEACETOXYAUSTROSPICATINE1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TOLYPORPHIN-A0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-C0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-F0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-H0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-B0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-D0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-G0.5 ug/mlPrinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
5'-METHOXYHYDNOCARPIN--Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., Lewis, K. 2000. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA, 97(4): 1433-1437.
TANGERETIN--*
TOLYPORPHIN--Smith, C. D., Prinsep, M. R., Caplan, F. R., Moore, R. E., Patterson, G. M. L. 1994. Reversal of Multiple Drug Resistance by Tolyporphin, a Novel Cyanobacterial Natural Product. Oncol. Res., 6: 211-218.
CONOPHYLLINE-QUINONE--Takahashi, K., Koyano, T., Komiyama, H., Kam, T. S. 1998. Conophylline Quinone as a New Antitumor Agent. Patent, Japan Kokai Tokkyo Koho-10 45,763. 5pp.
HOMOHARRINGTONINE--Qian, Q. J., Han, J. L., Yan, W. W., Yang, C. Z., Han, D. S., Shi, H., Hao, Y. 1996. A Comparative Study on the Mechanism of Homoharringtonine (HHI) and Melphalan (MEL) Resistance in K562/H20 and K562/MEL Cell Lines. Zhonghua Xueyexue Zazhi,17(7):354-356.
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