Chemical Dosage References
ZEAXANTHIN--Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
WITHAPHYSACARPINED50=0.43 uMKennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
URSOLIC-ACID5 ug/mlLee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44.
TRANS-CHALCONE--Lee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44.
TAMARIXETIN--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
SULPHORAPHANEED50=0.43 uM*
SULFORAPHANE15 uM igs musZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
SULFORAPHANEIC50=11 uM*
SULFORAPHANE15 uM gas musCho, C. G., Posner, G. H., Talalay, P., Zhang, Y. S. 1995. Chemoprotective Isothiocyanates. Patent-US-5,411,986: 1-22.
SULFORAPHANEIC50=5-0.03 ug/mlLee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44.
SPIRAEOSIDE--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
SINIGRIN15 uMTawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
RHAMNETIN--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
RESVERATROLED100=21 uM*
QUERCETIN-4'-GLUCOSIDE30 uMWillaimason, G., Plumb, G. W., Uda, Y., Price, K. R., Rhodes, M. J. C. 1996. Dietary Quercetin Glycosides: Antioxidant Activity and Induction of the Anticarcinogenic Phase II Marker Enzyme Quinone Reductase in Hepalclc7 Cells. Carcinogenesis 17(11): 2385.
QUERCETIN6 uMUda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
QUERCETIN13 uM*
PYROCATECHOL--Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
PURPURINIC50>50.7 uM*
PROGOITRIN15 uMTawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
PONGAMOLED50=6.1 uM*
PONGAMOLIC50=18.7 uM*
PHENETHYL-ISOTHIOCYANATE1 uM/kgGuo, Z., et al. 1992. Effects of Phenethyl Isothiocyanate, a Carcinogenesis Inhibitor, on Xenobiotic-Metabolizing Enzymes and Nitrosamine Metabolism in Rats. Carcinogenesis, 13(12): 2205-2210.
NEOGLUCOBRASSICIN100 uMFahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
MYRICETIN36 uMUda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
MEDICARPINIC50>74.8 uM*
LUTEIN2.5 ugMadhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
LANCEOLATIN-B22.9 uM*
LANCEOLATIN-BIC50=>76.3 uM*
L-MAACKIAINIC50=>13.4 uM*
KAEMPFEROL3 uM*
KAEMPFERIDE--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
JUGLONE20 uMDuhaiman, A. S. 1996. Characterization of Zeta-Crystallin Inhibition by Juglone. Biochem. Biophys. Res. Commun., 218(3): 648-652.
ISORHAMNETIN--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
IRILONE--*
INDOLE-3-CARBINOL50 mg/kg igs musShertzer, H. G., Sainsbury, M. 1991. Intrinsic Acute Toxicity and Hepatic Enzyme Inducing Properties of the Chemoprotectants Indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in... Fold Chem Toxicol, 29(4): 237-242.
IBERVERIN3.5 uMZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
IBERIN2.4 uMZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
GLUCORAPHANIN1 uMFahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
GLUCONASTURTIN15 uMTawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCONAPIN--Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCOIBERIN15 uMTawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCOBRASSICIN100 uMFahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
GLUCOBRASSICANAPIN15 uMTawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GENISTEINIC50=4.6 ug/ml*
GALANGIN4 uMUda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
GALANGAL-ACETATE50 mg/kg igs ratTanaka, T., et al. 1997. Chemoprevention of Azoxymethane-Induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-acetoxychavicol acetate. Jap. J. Cancer Res., 88(9): 821-830.
ERYSOLIN5.0 uMZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
ERUCIN15 uM/day igs musZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
ELLAGIC-ACID0.4 g/kg ratAhn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828.
DIALLYL-DISULFIDE0.3 mg/kg*
DEMETHOXYCURCUMIN12.5 uMSingletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
DEMETHOXYCURCUMIN1% diet ratSingletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
DAIDZEIN--Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
CYCLOBRASSININ.22 uMMehta, R. G., Liu, J. F., Constantinou, A., Thomas, C. E., Hawthorne, M., You, M., Gerhauser, C., Pezzuto, J. M., Moon, R. C., Moriarty, R. M. 1995. Cancer Chemopreventive Activity of Brassinin, a Phytoalexin from Cabbage. Carcinogenesis, 16(2): 399-404.
CURCUMIN3.4 uMSingletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
CHEIROLIN1.3 uMZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
CATECHOL--Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
CARNOSOL100 mg/kg ipr ratSingletary, K. W. 1996. Rosemary Extract and Carnosol Stimulate Rat Liver Glutathione-s-transferase and Quinone Reductase Activities. Cancer Lett., 100: 139-144.
BRASSININ0.22 uMMehta, R. G., Liu, J. F., Constantinou, A., Thomas, C. E., Hawthorne, M., You, M., Gerhauser, C., Pezzuto, J. M., Moon, R. C., Moriarty, R. M. 1995. Cancer Chemopreventive Activity of Brassinin, a Phytoalexin from Cabbage. Carcinogenesis, 16(2): 399-404.
BIS-DEMETHOXYCURCUMIN11.9 uMSingletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
BERTEROIN1.7 uMZhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BAICALIN--*
AURAPTENE100 ppm*
AURAPTENE400 mg/kg igs ratTanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
APIGENIN20 uMUda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
ALYSSIN0.95 uM*
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONEIC50>63.7 uM*
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE--Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
4-HYDROXY-GLUCOBRASSICIN100 uMFahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONEED50=17.2 uM*
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPINED50=7.8 uMKennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
24,25-DIHYDROWITHANOLIDE-DED50=0.7 uMKennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
(1'S)-1'-ACETOXYCHAVICOL-ACETATE--*
(-)-MEDICARPINED50=13.7 uM*
(-)-MAACKIAINED50=8.8 uM*
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPANIC50=>63.7 uM*
(+)-TEPHROPURPURINED50=0.15 uM*
(+)-TEPHROPURPURINIC50 13.4 uM*
(+)-PURPURINED50=5.6 uM*