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Chemical Dosage References
LASIOCARPINE-N-OXIDE L50=600 (ipr rat)Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp.
BRUCEIN-A ID50=0.0131 ug/ml*
MONOCROTALINE IC95=90 mg/kg*
SPECTABILINE IC95=90 mg/kg*
ATRACTYLOSIDE IC70 3 mM*
SAIKOSAPONIN IC50=5-100ug/ml*
(1'S)-1'-ACETOXYCHAVICOL-ACETATE IC50=1.5 uM*
3-(3,3-DIMETHYLALLYL)-5-(3-ACETYL-2,4-DIHYDROXY-5-METHYL-6-METHOXYBENZYL)-PHLORACETOPHENONE IC50-0.6 ug/ml*
HYDROXYVERNOLIDE IC50(P-388)=0.92*
1,2,11,13,2,3'-HEXAHYDROVERNODALIN IC50(P-388)=0.52*
4,15-DIHYDROVERNODALIN IC50(P-388)=0.07*
4,5-DIHYDROVERNODALIN IC50(P-388)=0.07*
HYDROXYVERNOLIDE IC50(L-1210)=1.25*
1,2,11,13,2,3'-HEXAHYDROVERNODALIN IC50(L-1210)=1.00*
4,15-DIHYDROVERNODALIN IC50(L-1210)=0.15*
4,5-DIHYDROVERNODALIN IC50(L-1210)=0.15*
ALPHA-PELTATIN ED=2 ppm ivn*
BETA-PELTATIN ED=2 ppm iv*
AMARALIN ED50{KB}=9.9*
BENZYL-BENZOATE ED50=8-15Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.