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All Chemicals: 81
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Chemical Dosage References
MAKALUVAMINE-G IC50=3 uMCarney, J. R., Scheuer, P. J., Kelly-Gorges, M. 1993. Makaluvamine G, a Cytotoxic Pigment From an Indonesian Sponge Histodermella sp. Tetrahedron, 49: 8483-8486.
MENADIONE 1 ug/mLFrydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
MITOMYCIN-C --Zhang, W. S., Lin, Z. K., Huang, X. T. 1990. Effect of Some Nonintercalative Antitumor Drugs on the Activity of Calf Thymus DNA Topoisomerase I. Yao Hsueh Hsueh Pao, 25: 641-645.
MONOMARGINE 10 ug/mlMahmood, K., Pais, M., Fontaine, C., Ali, H. M., Hamid, A., Hadi, A., Guittet, E. 1993. Monomargine, a Nitrogenous Cytotoxic Pigment From Monocarpia marginalis. Tetrahedron Letters, 34: 1795-1796.
MORIN IC50=42.1 ug/ml (weak activity)Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
MYRICETIN IC50=11.9 ug/ml*
NARINGENIN --Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
NEOAMPHIMEDINE --De Guzman, F. S., et al. 1999. Neoamphimedine: A New Pyridoacridine Topoisomerase II Inhibitor Which Catenates DNA. J Org Chem, 64: 1400-1402.
NORHARMAN ED50=34.4 ug/ml (weak activity)Funayama, Y., Nishio, K., Kabayashi, K., Nagao, M., Shimoi, K., Ohira, T., Hasegawa, S., Saijo, N. 1996. Effects of Beta- and Gamma-carboline Derivatives on DNA Topoisomerase Activities. Mutat Research, 249: 183-191.
NOVOBIOCIN 150 uMConstantinou, A., Henning-Chubb, C., Huberman, E. 1989. Novobiocin- and Phorbol-12 myristate-13-acetate-Induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity. Cancer Research, 49: 1110-1117.
PEDUNCULAGIN 0.03 ug/mlOoishi, K., Kato, J., Hayamizu, K. 1994. Topoisomerase Inhibitors Containing Tannins, Especially Pedunculagin, for Treatment of Cancer. Patent, Japan Kokai Tokkyo Koho-06 72,885. 7pp.
QUERCETIN IC50=12.8 ug/ml*
RABDOSIN 50 uMKashiwada, Y., Bastow, K. F., Lee, K. H. 1995. Novel Lignan Derivatives as Selective Inhibitors of DNA Topoisomerase II. Bioorg Med Chem Lett, 5: 905-908.
RUBRAXANTHONE IC50=60 ug/mlIinuma, T., Nozaki, H. 1998. Antitumor Agents Containing Xanthones as Topoisomerase Inhibitors. Patent, Japan Kokai Tokkyo Koho-10 203,977. 10pp.
SANGUIIN-H-6 IC50=0.02-5 uMBastow, K.F., Bori, I.D., Fukushima, Y., Kashiwada, Y., Tanaka, T., Nonaka, G., Nishioka, I., Lee, K.H. 1993. Inhibition of DNA Topoisomerases by Sanguiin H-6, a Cytotoxic Dimeric Ellagitannin From Sanguisorba officinalis. Planta Medica, 59: 240-245.
VELUTIN 0.1 ug/mlZahir, A., Jossang, A., Bodo, B., Provost, J., Cosson, J. P., Sevenet, T. 1996. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones From Lethedon tannaensis. J Natural Products, 59: 701-703.
WAKAYIN 6.7 nMKokoshka, J. M., Capson, T. L., Holden, J. A., Ireland, C. M., Barrows, L. R. 1996. Differences in the Topoisomerase I Cleavage Complexes Formed by Camptothecin and Wakayin, a DNA-Intercalating Marine Natural Product. Anticancer Drugs, 7: 758-765.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.