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All Chemicals: 81
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Chemical Dosage References
DOTRIACOLIDE 2.6 ug/mlOgawara, H., Horikawa, S., Yanagida, T., Nakno, M. M., Andoh, T., Ishii, K., Hori, M., Goto, T. A., Hamada, M., Umezawa, H. 1982. A Novel Deoxyribonuclease Inhibitor From Micromonospora. J Antibiot, 35: 248-250.
NOVOBIOCIN 150 uMConstantinou, A., Henning-Chubb, C., Huberman, E. 1989. Novobiocin- and Phorbol-12 myristate-13-acetate-Induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity. Cancer Research, 49: 1110-1117.
7-HYDROXY-FLAVONE 100 ug/ml*
MONOMARGINE 10 ug/mlMahmood, K., Pais, M., Fontaine, C., Ali, H. M., Hamid, A., Hadi, A., Guittet, E. 1993. Monomargine, a Nitrogenous Cytotoxic Pigment From Monocarpia marginalis. Tetrahedron Letters, 34: 1795-1796.
CAMPTOTHECIN 1-50 uM*
GENISTEIN 1-10 ug/mlOkura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
DIHYDROTANSHINONE-I 1 uMLee, D. S., Lee, S. H., Kwon, G. S., Lee, H. K., Woo, J. H., Kim, J. G., Hong, S. D. 1999. Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge. Biosci. Biotech. Biochem., 63: 1370-1373.
MENADIONE 1 ug/mLFrydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
3',5',7-TRI-O-METHYLTRICETIN 1 ug/mLZahir, A., Jossang, A., Bodo, B., Provost, J., Cosson, J. P., Sevenet, T. 1996. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones From Lethedon tannaensis. J Natural Products, 59: 701-703.
BETA-LAPACHONE 1 ug/mLFrydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
CHARTREUSIN 1 ug/mLYoshida, T., Habuka, N., Takeuchi, M., Ichishima, E. 1986. Inhibition of DNA Topoisomerase I From Alcaligenes sp. by Chartreusin. Agr Biol Chem, 50: 515-516.
10-HYDROXYCAMPTOTHECIN 0.4-1 uM*
HALENAQUINONE 0.3 ug/mlBae, M. A., Tsuji, T., Kondo, K., Hirase, T., Ishibashi, M., Shigemori, H., Kobayashi, J. I. 1993. Inhibition of Mammalian Topoisomerase I by Xestoquinone and Halenaquinone. Biosci. Biotech. Biochem., 57: 330-331.
5,6-DIHYDRO-8-DEMETHYLCORYALYNE 0.26 uMPilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
FAGARONINE 0.15-100 uM*
NITIDINE 0.15 uM*
VELUTIN 0.1 ug/mlZahir, A., Jossang, A., Bodo, B., Provost, J., Cosson, J. P., Sevenet, T. 1996. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones From Lethedon tannaensis. J Natural Products, 59: 701-703.
CAFFEINE 0.1 nMTohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132.
PEDUNCULAGIN 0.03 ug/mlOoishi, K., Kato, J., Hayamizu, K. 1994. Topoisomerase Inhibitors Containing Tannins, Especially Pedunculagin, for Treatment of Cancer. Patent, Japan Kokai Tokkyo Koho-06 72,885. 7pp.
BIOCHANIN-A --Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.