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All Chemicals: 81
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Chemical Dosage References
XESTOQUINONE IC50=0.15 ug/mlBae, M. A., Tsuji, T., Kondo, K., Hirase, T., Ishibashi, M., Shigemori, H., Kobayashi, J. I. 1993. Inhibition of Mammalian Topoisomerase I by Xestoquinone and Halenaquinone. Biosci. Biotech. Biochem., 57: 330-331.
SANGUIIN-H-6 IC50=0.02-5 uMBastow, K.F., Bori, I.D., Fukushima, Y., Kashiwada, Y., Tanaka, T., Nonaka, G., Nishioka, I., Lee, K.H. 1993. Inhibition of DNA Topoisomerases by Sanguiin H-6, a Cytotoxic Dimeric Ellagitannin From Sanguisorba officinalis. Planta Medica, 59: 240-245.
NORHARMAN ED50=34.4 ug/ml (weak activity)Funayama, Y., Nishio, K., Kabayashi, K., Nagao, M., Shimoi, K., Ohira, T., Hasegawa, S., Saijo, N. 1996. Effects of Beta- and Gamma-carboline Derivatives on DNA Topoisomerase Activities. Mutat Research, 249: 183-191.
HARMAN ED50=23.8 ug/ml (weak)Funayama, Y., Nishio, K., Kabayashi, K., Nagao, M., Shimoi, K., Ohira, T., Hasegawa, S., Saijo, N. 1996. Effects of Beta- and Gamma-carboline Derivatives on DNA Topoisomerase Activities. Mutat Research, 249: 183-191.
CAMPTOTHECIN ED50=0.8 uMHertzberg, R. P., et al. 1989. Modification of the Hydroxy Lactone Ring of Camptothecin: Inhibition of Mammalian topoisomerase I and Biological Activity. J Med Chem, 32: 715-720.
APIODIONEN 83 ug/mlTakahashi, H., Shiraishi, A., Iizuka, Y., Furuya, K., Kagasaki, T. 1992. Manufacture of Anticancer and Anti-Inflammatory Apiodionen With Apiosordaria. Patent, Japan Kokai Tokkyo Koho-04 49,289. 8pp.
CAFFEINE 75 uMShin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
WAKAYIN 6.7 nMKokoshka, J. M., Capson, T. L., Holden, J. A., Ireland, C. M., Barrows, L. R. 1996. Differences in the Topoisomerase I Cleavage Complexes Formed by Camptothecin and Wakayin, a DNA-Intercalating Marine Natural Product. Anticancer Drugs, 7: 758-765.
ISORABDOSIIN 50 uMKashiwada, Y., Bastow, K. F., Lee, K. H. 1995. Novel Lignan Derivatives as Selective Inhibitors of DNA Topoisomerase II. Bioorg Med Chem Lett, 5: 905-908.
RABDOSIN 50 uMKashiwada, Y., Bastow, K. F., Lee, K. H. 1995. Novel Lignan Derivatives as Selective Inhibitors of DNA Topoisomerase II. Bioorg Med Chem Lett, 5: 905-908.
CRYPTOLEPINE 5 uMBonjean, K., et al. 1998. The DNA Intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primarily DNA Synthesis in B16 Melanoma Cell. Biochemistry, 37: 5136-5146.
AMAROGENTIN 5 uMRay, S., Majumder, H.K., Chakravarty, A.K., Mukhopadhyay, S., Gil, R.R., Cordell, G.A.1996.Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I From Leishmania donovani. J Natural Products, 59: 27-29
FREDERICAMYCIN-A 4.4 uMLatham, M. D., King, C. K., Gorycki, P., MacDonald, T. L., Ross, W. E. 1989. Inhibition of Topoisomerases by Fredericamycin A. Cancer Chemother Pharmacol, 24: 167-171.
8-DEMETHYLCORALYNE 26 uMPilch, D. S., et al. 1997. Minor Groove-Directed and Intercalative Ligand-DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs. Biochemistry, 36: 12542-12543.
EPIBERBERINE 250 uMKobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
GROENLANDICINE 250 uMKobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
BETA-LAPACHONE 250 uMLi, C. J., Verboukh, L., Pardee, A. B. 1993. Beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecin. J Biol Chem, 268: 22463-22468.
DIHYDRODAIDZEIN 250 ppm (weak activity)Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
DIHYDROGENISTEIN 250 ppmChang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
BIS-DEMETHOXYCURCUMIN 25 ug/ml*
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.