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Chemical Dosage References
CHEBULANIN MIC=0.1 ug/mlTokura, K., Kagawa, S. 1993. Anticancer Agents Containing Chebulanin From Terminalia chebula. Patent, Japan Kokai Tokkyo Koho-07 138,165. 4pp.
ALPHA-BOSWELLIC-ACID-ACETATE IC>80=5 uM*
CAMPTOTHECIN IC50=670 nMLuzzio, M. J., et al. 1995. Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I. J Med Chem, 38: 395-401.
RUBRAXANTHONE IC50=60 ug/mlIinuma, T., Nozaki, H. 1998. Antitumor Agents Containing Xanthones as Topoisomerase Inhibitors. Patent, Japan Kokai Tokkyo Koho-10 203,977. 10pp.
EQUOL IC50=50 ppmChang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
CHEBULAGIC-ACID IC50=50 nM*
MORIN IC50=42.1 ug/ml (weak activity)Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
QUERCETIN IC50=42 uM*
CORILAGIN IC50=40 uMHecht, S. M., Berry, D. E., MacKenzie, L. J., Busby, R. W., Nasuti, C. A. 1992. A Strategy For Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I. J Natural Products, 55: 401-413.
MAKALUVAMINE-G IC50=3 uMCarney, J. R., Scheuer, P. J., Kelly-Gorges, M. 1993. Makaluvamine G, a Cytotoxic Pigment From an Indonesian Sponge Histodermella sp. Tetrahedron, 49: 8483-8486.
GENISTEIN IC50=250 ppm*
EPIMANOALIDE-25-ACETAL IC50=25 uMKobayashi,M., Okamoto,T., Hayashi,K., Yokayama,N., Sasaki,T., Kitagawa,I. 1994. Marine Natural Products. XXXII. Absolute Configurations of C-4 of the Manoalide Family, Biologically Active Sesterterpenes From the Marine Sponge. Chem Pharm Bull, 42: 265-270
FISETIN IC50=20.6 ug/ml*
4-NEROLIDYL-CATECHOL IC50=20 ug/mlMonqelli, E., Aromano, a., Desmarchelier, C., Coussio, J., Ciccia, G. 1999. Cytotoxic 4-nerolidylcatechol From Pothomorphe peltata Inhibits Topoisomerase I Activity. Planta Medica, 65: 376-378.
SANSALVAMIDE-A IC50=124 um*
QUERCETIN IC50=12.8 ug/ml*
MYRICETIN IC50=11.9 ug/ml*
BETA-LAPACHONE IC50=1 uMWeller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
CAMPTOTHECIN IC50=1 uMWeller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
20(S)-CAMPTOTHECIN IC50=0.52 uMWall, M.E., Wani, M.C., Nicholas, A.W., Manikumar, G., Tele, C., Moore, L., Truesdale, A., Leitner, P., Besterman, J.M. 1993. Plant Antitumor Agents. 30. Synthesis and Structure Activity of Novel Camptothecin Analogs. J Med Chem, 36: 2689-2700.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.