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All Chemicals: 113
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Chemical Dosage References
LAHADININE-A IC50=2.5 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
LYCACONITINE IC50=74 ug/mlKim, D. K., Kwon, H. Y., Lee, K. R., Rhee, D. K., Zee, O. P. 1998. Isolation of a Multidrug Resistance Inhibitor From Aconitum pseudo-laeve var. erectum. Arch Pharm Research, 21: 344-347.
PLEIOCARPINE IC50=3.1 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
PUERARIN --*
QUINIDINE IC50=1-12 uM*
QUINIDINE 100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
QUININE IC50=4-17 uM*
RESERPINE 2.5-10 uM*
TANGERETIN --*
TAXACIN 10 ug/mlKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXACUSTIN 1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAGIFINE 1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAYUNTIN 1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXCHININ-B 1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXINE-II 1 ug/mL*
TAXININE 1 ug/mL*
TAXININE-A 1 ug/mL*
TAXININE-B 1-10 ug/ml*
TAXININE-M 1 ug/mLKobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-A 1 ug/mL*
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.