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Chemical Dosage References
DIOSMIN 100 uMCritchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
GENISTEIN 200 uMCastro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93.
GINSENOSIDE-RB-1 100 uM catHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RB-2 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RC 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RD 50 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RE 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-1 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-2 25 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RG-1 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RG-2 100 uMHasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
HAPALOSIN 20 uMStratmann, K., Burgoyne, D. L., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1994. Hapalosin, a Cyanobacterial Cyclic Depsipeptide With Multidrug-Resistance Reversing Activity. J Org Chem, 59(24): 7219-7226.
HOMOHARRINGTONINE --Qian, Q. J., Han, J. L., Yan, W. W., Yang, C. Z., Han, D. S., Shi, H., Hao, Y. 1996. A Comparative Study on the Mechanism of Homoharringtonine (HHI) and Melphalan (MEL) Resistance in K562/H20 and K562/MEL Cell Lines. Zhonghua Xueyexue Zazhi,17(7):354-356.
INOSTAMYCIN 10 uM*
ISORESERPINE 1.6 uMHall, A. M., Croy, V., Chan, T., Ruff, D., Kuczek, T., Chang, C. J. 1996. Bicinchoninic Acid Protein Assay in the Determination of Adriamycin Cytotoxicity Modulated by the MDR Glycoprotein. J Nat Prod, 59(1): 35-40.
KOPSAMINE IC50=5.6 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSIFLORINE IC50=5.6 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSILONGINE IC50=15.4 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSININE IC50=25 ug/mlKam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.