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Chemical Dosage References
EUGENOL-ACETATE 1 mM rbtChen, S. J., Wang, M. H., Chen, I. J. 1996. Antiplatelet and Calcium Inhibitory Properties of Eugenol and Sodium Eugenol Acetate. Gen Pharmacol, 27(4): 629-633.
FALCARINOL --Fujimoto, Y., et al. 1998. Inhibition of 15-hydroxyprostaglandin Dehydrogenase Activity in Rabbit Gastric Antral Mucosa by Panaxynol Isolated from Oriental Medicines. J Pharmacy & Pharmacology, 50(9): 1075-1078.
FERULIC-ACID 0.58-3.2 mMXu, L. N., Yu, W. G., Tian, J. Y., Liu, Q. Y. 1990. Effect of Sodium Ferulate on Arachidonic Acid Metabolism. Yao Hsueh Hsueh Pao, 25(6): 412-416.
GALLIC-ACID-PROPYL-ESTER IC50=100 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
GINSENOSIDE-RC 500 ug/mlPark, C. W. 1992. The Effects of Ginseng Components on Arachidonic Acid Metabolism. Korean J Ginseng Science, 16(1): 69-71.
GLAUCOCALYXIN-A 10 uM rbtZhang, B., Long, K., Jiang, Y. Y. 1992. Effects of Glaucocalyxin a on PAF Biosynthesis and Arachidonic Acid Metabolism in Washed Rabbit Platelets. Zhongguo Yaolixue ye Dulixue Zazhi, 6(1): 52-55.
GLYCYRRHIZIN 100 mg/kg igs musRen, J., Cheng, J. X., Wang, Z. G. 1988. Effects of Ammonium Glycyrrhizinate on the Synthesis of Prostaglandins E2 and F2-alpha. K'o Hsueh T'ung Pao, (3): 227-229.
GOSSYPOL 8.4-380 nMXiao, D. M., Wang, X. L., Zhang, J. B., Chen, H. C. 1991. Effects of Gossypol of Phorbol Ester-Calcimycin-induced Prostaglandin Synthesis by Macrophages. Chin Med J, 104(4): 321-325.
GUAIACOL IC50=57 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
LABDA-TRANS-8(17)-12-DIENE-15-16-DIAL IC50=100 uMKawakishi, S., Morimitsu, Y., Osawa, T. 1994. Chemistry of Ginger Components and Inhibitory Factors of the Arachidonic Acid Cascade. ASC Symp Ser, 547: 244-250.
MYRICETIN-3-O-BETA-D-GLUCURONIDE 1 ug rbtHiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
NORATHYRIOL IC50=29.1 mg/kg ipr musWang, J. P., Ho, T. F., Lin, C. N., Tang, C. M. 1994. Effect of Norathryiol, Isolated from Tripterospermum lanceolatum, on A23 187-Induced Pleurisy and Analgesia in Mice. Naunyn-Schmiedeberg's Arch Pharmacol, 350(1): 90-95.
OLEANOLIC-ACID igs mus*
P-COUMARIC-ACID --*
PYROGALLOL IC50=900 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
QUERCETIN 40 ug/mlIbewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
SALIPURPOSIDE IC50=13.14 uMOgundaini, A., Farah, M., Perera, P., Samuelsson, G., Bohlin, L. 1996. Isolation of two new Antiinflammatory Biflavanoids from Sarcophyte piriei. J Natural Products, 59(6): 587-590.
SHIKONOFURAN-B 20 ug/ml (72% inhibition)Yao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
SHIKONOFURAN-C 20 ug/ml (72% inhibition)Yao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
SINOMENINE IC50=1 mMLiu, L, Riese, J., Resch, K., Kaever, V. 1994. Impairment of Macrophage Eicosanoid and Nitric Oxide Production by an Alkaloid from Sinomenium acutum. Arzneim-Forsch, 44(11): 1223-1226.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.