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All Chemicals: 62
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Chemical Dosage References
6-GINGEROL 1 mM (60.7% inhibition)*
8-BETA-17-EPOXY-LABD-TRANS-12-ENE-15,16-DIAL IC50=100 uMKawakishi, S., Morimitsu, Y., Osawa, T. 1994. Chemistry of Ginger Components and Inhibitory Factors of the Arachidonic Acid Cascade. ASC Symp Ser, 547: 244-250.
AESCULETIN 100 uM rbtHung, H.C., Lai, M.W., Wang, H.R., Chung, Y.L., Hsieh, L.M., Chen, C.C. 1993. Antiproliferative Effect of Esculetin on Vascular Smooth Muscle Cells: Possible Roles of Signal Transduction Pathways. Eur J Pharmacol, 237(1): 39-44.
ALPHA-LINOLENIC-ACID 39.5 g/day/hmnFerretti, A., Flanagan, V. P. 1996. Antithromboxane Activity of Dietary Alpha-linolenic Acid: A Pilot Study. Prostaglandins Leukotrienes Essential Fatty Acids, 54(6): 451-455. ARS, USDA.
ALPHITOL IC50=0.66 mMDunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
ARNEBINONE 20 ug/mlYao, X. S., et al. 1991. Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis. Chem & Pharm Bull, 39(11): 2956-2961.
AVAROL 3 ug/mlSchroder,H.C., Begin,E., Klocking,R., Matthes,E., Sarma,A.S., Gasic,M., Muller,W.E.G.1991.Avarol Restores the Altered Prostaglandin and Leukotriene Metabolism in Monocytes Infected with Human Immunodeficiency Virus Type I. Virus Research, 21(3):213-223.
BERBERASTINE 25 mg/kg ivn rbtHuang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
BERBERINE 25 mg/kg ivn rbtHuang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
BETULIN IC50=119 uMHuang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
BETULINIC-ACID IC50=101 uMHuang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
BETULINIC-ACID 200 ug/mlDunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
BOLDINE 25 uM ratBackhouse, N., Delporte, C., Givernau, M., Cassels, B. K., Valenzuela, A., Speisky, H. 1994. Anti-Inflammatory and Antipyretic Effects of Boldine. Agents & Actions, 42(3/4): 114-117.
CAFFEIC-ACID-MALATE IC50=38 ug/mlObertreis, B., Giller, K., Teucher, T., Behnke, B., Schmitz, H. 1996. Antiphlogistic Effects of Urtica dioica folia Extract in Comparison to Caffeic Malic Acid. Arzneim-Forsch, 46(1): 52-56.
CURCUMIN 0.2% diet ratRao, C. V., Rivenson, A., Simi, B., Reddy, B. S. 1995. Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Research, 55(2): 259-266.
DIINSINIOL IC50=9.2 uM (weak activity)Ogundaini, A., Farah, M., Perera, P., Samuelsson, G., Bohlin, L. 1996. Isolation of two new Antiinflammatory Biflavanoids from Sarcophyte piriei. J Natural Products, 59(6): 587-590.
EMODIN IC50=23 uM/mlMueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414.
ENT-8-ALPHA-HYDROXY-LABDA-13(16),14-DIENE IC50=3 uM musDe Las Heras, B., Hoult, J. R. S. 1994. Non-Cytotoxic Inhibition of Macrophage Eicosanoid Biosynthesis and Effects on Leukocyte Functions and Reactive Oxygen Species of two Novel-Anti-Inflammatory Plant Diterpenoids. Planta Medica, 60(6): 501-506.
EUGENOL IC50=9.2 uM*
EUGENOL 1 mM rbtChen, S. J., Wang, M. H., Chen, I. J. 1996. Antiplatelet and Calcium Inhibitory Properties of Eugenol and Sodium Eugenol Acetate. Gen Pharmacol, 27(4): 629-633.
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.