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Chemical Dosage References
TANSHINONE igs rbtLi, X. H., Tang, R. 1991. Relationship Between Inhibitory Action of Tanshinone on Neutrophil Function and its Prophylactic Effects on Myocardial Infarction. Chung-Kuo Yao Li Hsueh Pao, 12(3): 269-272.
OLEANOLIC-ACID igs mus*
1,2,4-TRIHYDROXY-BENZENE IC50=900 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
PYROGALLOL IC50=900 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
DIINSINIOL IC50=9.2 uM (weak activity)Ogundaini, A., Farah, M., Perera, P., Samuelsson, G., Bohlin, L. 1996. Isolation of two new Antiinflammatory Biflavanoids from Sarcophyte piriei. J Natural Products, 59(6): 587-590.
EUGENOL IC50=9.2 uM*
GUAIACOL IC50=57 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
3-METHYL-ETHER-6-C-METHYLQUERCETIN IC50=55.4 uMIbewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
1,3,5-TRIHYDROXY-BENZENE IC50=45 uMAlanko, J., et al. 1999. Modulation of Arachidonic Acid Metabolism by Phenols: Relation to their Structure and Antioxidant/Proooxidant Properties. Free Radical Biol Med, 26(1/2): 193-201.
3,3',7-TRIMETHYL-ETHER-6-C-METHYLQUERCETIN IC50=4.5 uMIbewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
CAFFEIC-ACID-MALATE IC50=38 ug/mlObertreis, B., Giller, K., Teucher, T., Behnke, B., Schmitz, H. 1996. Antiphlogistic Effects of Urtica dioica folia Extract in Comparison to Caffeic Malic Acid. Arzneim-Forsch, 46(1): 52-56.
(-)-MELLEIN IC50=340 uMPongprayoon, U. 1991. Pharmacognostic Studies on the Thai Medicinal Plant Ipomoea pes-caprae (L.) R.BR. (Pak Bung Ta Lae). Acta Pharm Nordica, 3(3). 186 pp.
ENT-8-ALPHA-HYDROXY-LABDA-13(16),14-DIENE IC50=3 uM musDe Las Heras, B., Hoult, J. R. S. 1994. Non-Cytotoxic Inhibition of Macrophage Eicosanoid Biosynthesis and Effects on Leukocyte Functions and Reactive Oxygen Species of two Novel-Anti-Inflammatory Plant Diterpenoids. Planta Medica, 60(6): 501-506.
NORATHYRIOL IC50=29.1 mg/kg ipr musWang, J. P., Ho, T. F., Lin, C. N., Tang, C. M. 1994. Effect of Norathryiol, Isolated from Tripterospermum lanceolatum, on A23 187-Induced Pleurisy and Analgesia in Mice. Naunyn-Schmiedeberg's Arch Pharmacol, 350(1): 90-95.
3,7-DIMETHYL-ETHER-6-C-METHYLQUERCETIN IC50=25.9 uMIbewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
2-HYDROXY-4,4,7-TRIMETHYL-(4H)-NAPHTHALEN-1-ONE IC50=230 uMPongprayoon, U. 1991. Pharmacognostic Studies on the Thai Medicinal Plant Ipomoea pes-caprae (L.) R.BR. (Pak Bung Ta Lae). Acta Pharm Nordica, 3(3). 186 pp.
EMODIN IC50=23 uM/mlMueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414.
3-METHYL-ETHER-6,8-DI-C-METHYLQUERCETIN IC50=23 uMIbewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.
(1S-2-TRANS-4S-6R-7-TRANS)-CEMBRA-2,7,12-(20-TRIENE-4,6,11-TRIOL) IC50=2.7 mMOlsson, E., Holth, A., Kumlin, E., Bohlin, L., Wahlberg, I. 1993. Structure-Related Inhibiting Activity of some Tobacco Cembranoids on the Prostaglandin Synthesis in vitro. Planta Medica, 59(4): 293-295.
4-VINYL-GUAIACOL IC50=18 uM*
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.