Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Chemical BETA-LAPACHONE

Chemical ID
BETALAPACHONE
Ubiquitous
No

Select a Results View:

Download these results as:
CSV
XLSX
List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Antitrypanosomic *
Reverse-Transcriptase-Inhibitor *
Topoisomerase-I-Inhibitor 250 uM Li, C. J., Verboukh, L., Pardee, A. B. 1993. Beta-lapachone, a Novel DNA Topoisomerase I Inhibitor With a Mode of Action Different From Camptothecin. J Biol Chem, 268: 22463-22468.
Topoisomerase-I-Inhibitor 1 ug/mL Frydman, B., et al. 1997. Induction of DNA Topoisomerase II-Mediated DNA Cleavage by Beta-lapachone and Related Naphthoquinones. Cancer Research, 57: 620-627.
Topoisomerase-I-Inhibitor IC50=1 uM Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
Loading content ...