Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Chemical SANGUIIN-H-6

Chemical ID
SANGUIINH6
Ubiquitous
No

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Antiangiogenic *
Topoisomerase-I-Inhibitor IC50=0.02-5 uM Bastow, K.F., Bori, I.D., Fukushima, Y., Kashiwada, Y., Tanaka, T., Nonaka, G., Nishioka, I., Lee, K.H. 1993. Inhibition of DNA Topoisomerases by Sanguiin H-6, a Cytotoxic Dimeric Ellagitannin From Sanguisorba officinalis. Planta Medica, 59: 240-245.
Topoisomerase-II-Inhibitor IC50=0.01-0.16 uM Bastow, K.F., Bori, I.D., Fukushima, Y., Kashiwada, Y., Tanaka, T., Nonaka, G., Nishioka, I., Lee, K.H. 1993. Inhibition of DNA Topoisomerases by Sanguiin H-6, a Cytotoxic Dimeric Ellagitannin From Sanguisorba officinalis. Planta Medica, 59: 240-245.
Topoisomerase-II-Inhibitor IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
VEGF-Inhibitor IC50=7.4 ug/ml *
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Rubus idaeus Leaf *
Rubus phoenicolasius Leaf Okuda, T., Yoshida, T., Hatano, T., Iwasaki, M., Kubo, M., Orime, T., Yoshizaki, M., Naruhashi, N. 1992. Hydrolysable Tannins as Chemotaxonomic Markers in the Rosaceae. Phytochemistry, 31(9): 3091-3096.
Sanguisorba officinalis Plant *