Chemical GENISTEIN | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

GENISTEIN

Ubiquitous

No

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
NADH-Ubiquinone-Oxidoreductase-Inhibitor	not available	Duke, 1992 *
Natriuretic	not available	Duke, 1992 *
Ornithine-Decarboxylase-Inhibitor	not available	Duke, 1992 *
Peroxidase-Inhibitor	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide	not available	Duke, 1992 *
Phytoalexin	not available	Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Pituitary-sensitizer	not available	Medline (post 1990 searches filed in my computer)
PTK-Inhibitor	10-100 uM	Duke, 1992 *
Quinone-Reductase-Inducer	IC50=4.6 ug/ml	Duke, 1992 *
Topoisomerase-I-Inhibitor	IC50=250 ppm	Duke, 1992 *
Topoisomerase-I-Inhibitor	1-10 ug/ml	Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
Topoisomerase-II-Inhibitor	IC50=1-150 uM	Duke, 1992 *
Topoisomerase-II-Inhibitor	2-7.5 ug/ml	Duke, 1992 *
Topoisomerase-II-Inhibitor	IC50=30 ug/ml	Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
Topoisomerase-II-Inhibitor	20 uM	Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117.
Topoisomerase-II-Poison	not available	Journal of Medicinal Food 2: 167.1999.
Trypanosomastat	not available	Medline (post 1990 searches filed in my computer)
Tyrosine-Kinase-Inhibitor	not available	Duke, 1992 *
Uterotrophic	EC50=0.1-25 uM/l	Duke, 1992 *
Uterotrophic	ED50=0.5 mg/kg	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Trigonella foenum-graecum	Seed	not available	10.0	-0.3	Duke, 1992 *
Ulex micranthus	Leaf	not available	not available	not available	Duke, 1992 *
Ulex sp	Leaf	not available	not available	not available	Duke, 1992 *
Vandasina retusa	Leaf Diffusate	not available	7.0	-0.4	Duke, 1992 *
Vicia faba	Seed	0.0	19.9	-0.3	Duke, 1992 *
Vigna angularis	Seed	not available	21.2	-0.3	Kaufman,PB,Duke,JA,Brielmann,H,Boik,J and Hoyt,JE. 1997. A Comparative Survey of Leguminous Plants as Sources of the Isoflavones Genistein and Daidzein: Implications For Human Nutrition and Health. Journal of Alternative & Complementary Medicine 3(1):7-12
Vigna angularis	Leaf Diffusate	not available	not available	not available	Duke, 1992 *
Vigna radiata	Seed	2.0	21.8	-0.3	Duke, 1992 *
Vigna radiata	Plant	not available	not available	not available	Stitt, Paul. Why George should eat broccoli.
Vigna subterranea	Leaf Diffusate	not available	6.0	-0.5	Duke, 1992 *
Vigna unguiculata	Seed	0.0	23.3	-0.3	Duke, 1992 *