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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. BERBERINE

BERBERINE

Chemical ID
BERBERINE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Antisalmonella *
Antisecretory *
Antiseptic 25 ug/ml *
Antishigellic 12.5 ug/ml Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antispasmodic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antispermigenic *
Antistaphylococcic *
Antistrep Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antisyphilitic *
Antitrachomic 0.20% *
Antitrypanosomic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antitubercular MIC=25 ug/ml *
Antitumor (brain) IC91=150 ug/ml Werbach & Murray, 1994.
Antiulcer *
Antivaginitic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Antiviral Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Astringent *
Bilirubinolytic *
Calcium-Antagonist Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
Candidicide *
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Adonis vernalis Plant *
Andira inermis Bark *
Argemone mexicana Plant 410.0 *
Berberis vulgaris Plant Jim Duke's personal files.
Berberis vulgaris Root 4000.0 64800.0 1.1 *
Berberis vulgaris Bark 45000.0 1.0 Jim Duke's personal files.
Berberis vulgaris Root Bark 25000.0 80000.0 *
Berberis vulgaris Stem Bark 20000.0 25000.0 1.0 Jim Duke's personal files.
Berberis vulgaris Flower 6600.0 Jim Duke's personal files.
Berberis vulgaris Stem 1600.0 28900.0 Jim Duke's personal files.
Berberis vulgaris Leaf 3000.0 1.0 Jim Duke's personal files.
Caulophyllum thalictroides Plant Jim Duke's personal files.
Chelidonium majus Plant *
Coptis chinensis Rhizome 40000.0 90000.0 0.9 *
Coptis japonica Rhizome 40000.0 70000.0 -0.3 *
Coptis spp Rhizome 40000.0 90000.0 0.9 *
Corydalis spp Plant *
Eschscholzia californica Shoot List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Hydrastis canadensis Plant *
Hydrastis canadensis Rhizome 50000.0 -1.5 *