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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Xanthine-Oxidase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
(-)-EPICATECHIN IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(-)-EPIGALLOCATECHIN IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(-)-EPIGALLOCATECHIN-GALLATE IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(1'S)-1'-ACETOXYCHAVICOL-ACETATE *
(Z,E)-2-(3,4-DIHYDROXYPHENYL)-ETHENYL-ESTER IC50=0.021 ug/ml Chem. & Pharm. Bull. 38: 1772.
(Z,E)-2-(3,5-DIHYDROXYPHENYL)-ETHENYL-ESTER IC50=0.124 ug/ml Chem. & Pharm. Bull. 38: 1772.
1,2,3,6-TETRA-O-GALLYOL-BETA-D-GLUCOSE IC50=12 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE IC50=39 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
1,3,4,6-TETRA-O-GALLOYL-BETA-D-GLUCOSE IC50=8 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
3,5-DI-O-CAFFEOYLQUINIC-ACID IC50=34 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
3-O-GALLOYLEPICATECHINS IC50=4-7 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
AESCULETIN IC52=10 uM *
ALLICIN 500 uM LAWSON in Koch, H. P. and Lawson, L. D., eds. 1996. Garlic- The
Science and therapeutic application of Allium sativum L. and related species. Williams & Wilkins, Baltimore. 329 pp.
ALLOPURINOL 0.021 ug/ml *
ALLOPURINOL IC50=0.17 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
APIGENIN 0.36 uM *
ASTRAGALIN-2''-GALLATE 50 uM *
ASTRAGALIN-6''-GALLATE 50 uM *
ATHYRIOL Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Ludwigia perennis Perennial ludwigia 1 0
Lycium chinense Wolfberry; Chinese Boxthorn; Chinese Matrimony Vine; Chinese Wolfberry; Gou Qi (Chin.); Lyciet de Chine (Fr.); Chinesischer Bocksdorn (Ger.); Daun Koki (Indones.); Spina Santa Cinese (Ital.); Kuko (Jap.); Kaukichai (Malays.) 1 0
Lycopersicon esculentum Tomato 3 8
Lycopodium clavatum Antler Herb; Clubmoss 3 0
Lycopus europeus European Bugle 2 0
Lycopus virginicus Bugle 4 0
Lythrum salicaria Purple Loosestrife 2 447, 000
Maclura pomifera Osage-Orange; Hedge Apple 3 209, 994
Magnolia denudata Hsin-I; Xin-Yi 1 0
Magnolia kobus Hsin-I; Xin-Yi 2 0
Magnolia officinalis Chinese Magnolia; Hou Pu; Magnolia-Bark 2 0
Mahonia aquifolium Oregon Grape; Blue Barberry; Holly Barberry; Holly Mahonia; Mountain Grape 1 0
Malus domestica Apple 11 3, 173.2000000029802
Malva neglecta Cheeses; Common Mallow 1 0
Mangifera indica Mango 3 241, 100
Manilkara zapota Sapodilla 1 64, 500
Maranta arundinacea Arrowroot; Bermuda Arrowroot 1 0
Marrubium vulgare Horehound; White Horehound 6 198, 000
Marsdenia reichenbachii Condurango 1 0
Matricaria recutita Annual Camomile; German Camomile; Wild Camomile 7 26, 070