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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
KUWANON-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICORICIDIN 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICURASIDE IC50=0.56 uM *
LINARIIN IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LINARIN IC20=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LONICERIN IC56=1uM; IC92=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN EC=3 ppm Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.
LUTEOLIN IC50=0.45 uM rat *
LUTEOLIN-7-GLUCOSIDE IC73=10 uM *
LUTEOLIN-7-GLUCOSIDE IC31=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC68=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC88=10 uM *
LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDURONIC-ACID IC50=3.1 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
MACROCARPAL-A IC50=2 uM *
MACROCARPAL-A IC50=10 uM *
MACROCARPAL-B IC50=2.8 uM *
MACROCARPAL-D IC50=2 uM *
MACROCARPAL-G IC50=2.7 uM *
MANDSHURIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
MANIFLAVONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Ulmus rubra Slippery Elm; Red Elm 2 46
Umbellularia californica California Bay 3 2, 200
Uncaria catechu Gambir; Pale Catechu 2 0
Uncaria guianensis Cat's Claw; Una de Gato; Garabato Colorado; Tambor Huasca; Ungunagi 4 0
Uncaria tomentosa Cat's Claw; Garabato Amarillo; Una de Gato 2 0
Urginea maritima European Squill 4 0
Urtica dioica European Nettle; Stinging Nettle 16 69, 250
Vaccinium corymbosum Blueberry 16 3, 878.0299999993294
Vaccinium macrocarpon Cranberry; Large Cranberry; American Cranberry 7 6, 600
Vaccinium myrtillus Bilberry; Whortleberry; Dwarf Bilberry 17 19, 170.044999998994
Vaccinium vitis-idaea Cowberry; Lingen; Lingonberry 8 5, 595
Valeriana officinalis Valerian; Common Valerian; Garden-Heliotrope 13 669, 675
Vandasina retusa 1 7
Vanilla planifolia Vanilla; Bourbon Vanilla 4 12, 200
Verbascum thapsus Mullein; Velvetplant; Flannelleaf; Flannelplant; Great Mullein 5 4, 010
Verbena officinalis Vervain 1 10, 000
Vetiveria zizanioides Cus-Cus; Vetiver; Cuscus Grass 1 495
Viburnum opulus Crampbark; European Cranberry Bush; Guelder Rose; Snowballbush 9 511, 630
Viburnum prunifolium Black Haw 6 90
Vicia faba Broadbean; Faba Bean; Habas 5 7, 724.699998855591