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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ASTRAGALIN IC30=1 uM *
ASTRAGALIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AURANTIOBTUSIN IC50=13.6 uM *
AVICULARIN IC84=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AVICULARIN IC32=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
AXILLARIN IC80=0.1 uM *
AXILLARIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
BAICALEIN IC50=0.98 ppm Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALEIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BAICALEIN IC50=0.98 rbt Kohda, H., Tanaka, S., Yamaoka, Y., Yahara, S., Nohara, T., Tanimoto, T., Tanaka, A. 1989. Studies on Lens-Aldose-Reductase Inhibitor in Medicinal Plants.II Active Constituents of Monochasma savatierii FRANCH, et MAXIM. Chem. Pharm. Bull. 37(11):3153-3154
BAICALIN IC42=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
BAICALIN IC50=13.6 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
BERBERINE-CHLORIDE IC100=14 nM *
BERBERINE-IODIDE IC100=33 nM *
BERBERINE-SULFATE IC100=13.5 nM *
BRAZILIN ED50=100 uM *
BREVIFOLIN-CARBOXYLIC-ACID IC50=2.4 uM Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
CAFFEIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
CAPILLARISIN IC50=0.22 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
CAPILLARISIN 10 uM rat Yamaguchi, T., Ueda, T., Sata, S., Mihashi, H. 1989. Aldose Reductase Inhibitors for Treatment of Diabetic Diseases. Patent, Japan Kokai Tokkyo Koho-01 228,914. 5pp.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Sterculia urens Karaya 1 0
Stevia rebaudiana Ca-A-E; Sweet Leaf of Paraguay; Stevia 10 3, 000
Stizolobium deeringianum 1 0
Strongylodon macrobotrys 1 8
Strychnos nux-vomica Nux-Vomica; Stychnine 1 0
Styrax benzoin Benzoin; Onycha; Styrax 1 0
Styrax tonkinensis Siam Benzoin 1 2
Symphytum officinale Comfrey 4 5, 932
Syringa vulgaris Lilac 3 1, 315
Syzygium aromaticum Clove; Clovetree 15 66, 921.40000152588
Syzygium cumini Aceituna Dulce; Jambolan; Java Plum 1 3, 990
Syzygium jambos Pomarrosa; Rose Apple 1 4, 770
Syzygium malaccense Malay Apple; Mammey Pomorrosa; Ohia 1 13, 845
Tabebuia heptaphylla Pau D'Arco 1 181
Tabebuia impetiginosa Pau d'arco; Taheebo 2 0
Tagetes erecta Marigold; Aztec Marigold 2 0
Tagetes lucida Sweet-Mace; Sweet-Scent Marigold; Sweet-Scent Mexican Marigold; Anise Marigold 4 692
Tagetes minuta Wild Marigold; Aztec Marigold; Dwarf Marigold; Mexican Marigold; Muster John Henry; Stinking-Roger 5 57, 600
Tagetes patula French Marigold 6 0
Tamarindus indica Tamarind; Kilytree; Indian Tamarind 4 7, 815